In keeping with a latest examine printed in Lasers in surgical procedure and drugsEPI-assisted (electronically managed pneumatic jet injector) remedy with bleomycin and lidocaine is an efficient, well-tolerated various to traditional needle injectors (CNI) in recalcitrant instances of keloid scars. Primarily based on the analysis outcomes, this feature is possible and straightforward to implement in such instances.

Treating keloids may be difficult. Intralesional bleomycin utilizing CNI is efficient, however is related to disadvantages. It requires repeated and painful injections. This examine evaluated the effectiveness, tolerability and affected person satisfaction of intralesional bleomycin with lidocaine administered utilizing EPI in recalcitrant keloids.

This retrospective examine concerned sufferers who obtained three intralesional EPI-assisted remedies with bleomycin and lidocaine. Affected person and Observer Scar Evaluation Scale (POSAS) at baseline and 4 to 6 weeks after the third remedy evaluated effectiveness. Ache scores, unwanted side effects, affected person satisfaction and the International Aesthetic Enchancment Scale (GAIS) have been additionally assessed.

An important findings from the analysis are:

· Fifteen included sufferers had >148 recalcitrant keloids.

· At baseline, the median whole POSAS doctor and affected person scores have been 40 and 41, respectively. At follow-up, this was diminished by 7 and 6 factors.

· The median ache scores throughout EPI-assisted injections have been decrease than these throughout CNI-assisted injections, at 2.5 versus 7.0, respectively.

· There have been gentle unwanted side effects.

· Sufferers have been “happy” or “very happy” with the remedies.

· In a single case, GAIS was “very improved”, “improved” in 9 sufferers and “unchanged” in 4 sufferers.

· Hyperpigmentation on the injection web site was a typical aspect impact.

Additional concluding, they stated that EPI-assisted remedy with bleomycin and lidocaine is an efficient, well-tolerated, patient-friendly various to CKD in sufferers with recalcitrant keloid scars. Additional analysis is required so as to add extra affirmation and enchancment.

In our clinic, for security causes, sufferers are handled with a bleomycin-lidocaine resolution of 1 USPE/ml, with a most dose of three ml, they stated.

A sensible setting and a patient-centered method have been the primary strengths of this examine.

Limitations of the examine embody the dearth of a management group, the brief period of follow-up, and the restricted pattern measurement of 15 sufferers.

Reference:

Bekkers, VZ et al. Needle-free, electronically managed jet injector remedy with bleomycin and lidocaine is efficient and effectively tolerated in sufferers with recalcitrant keloids. Lasers in surgical procedure and drugs. https://doi.org/10.1002/lsm.23737