December 11, 2023 – Sufferers who obtained the anticoagulant drug warfarin after alternative of a bioprosthetic aortic valve had a decrease incidence of loss of life and a lowered threat of blood clots, in line with a retrospective examine revealed in Mayo Clinic Proceedings.

The usage of bioprosthetic aortic valve alternative has elevated considerably over the previous decade. One of many benefits is that almost all sufferers can keep away from warfarin for anticoagulation remedy. But analysis is conflicting as as to whether sufferers would profit from extra aggressive early postoperative anticoagulation remedy.

Mayo Clinic researchers analyzed nationwide knowledge from greater than 10,000 sufferers who underwent bioprosthetic aortic valve alternative. Warfarin use was related to a 32% discount in mortality threat. Sufferers handled with warfarin early postoperatively additionally had an elevated threat of main bleeding.

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